The loss of GluA1 leads to an increase in depression-associated learned helplessness (Chourbaji et al., 2008), hyperlocomotion in the open field (Wiedholz et al., 2008), novelty- and stress-induced locomotor hyperactivity, altered coping in the forced swim test and in approach-avoidance conflict tests (Fitzgerald et al., 2010), cognitive impairments in short-term memory, puzzle-solving and attention (Zamanillo et al., 1999; Bannerman et al., 2004; Sanderson et al., 2009; Ben Abdallah et al., 2011; Austen et al., 2021; Strickland et al., 2021). Here, GRIA1 is linked to depressive symptom measurement.