GRIA1 and major depressive disorder: GluA1 knockout mice represent a well-known animal model for depression based on mutation of the AMPA receptor subunit 1 (Zamanillo et al., 1999; Bannerman et al., 2004; Chourbaji et al., 2008; Wiedholz et al., 2008; Sanderson et al., 2009, 2017; Fitzgerald et al., 2010; Inta et al., 2010; Bygrave et al., 2016, 2019; Eltokhi et al., 2020; Ang et al., 2021), which is consistent with the glutamate hypothesis of depression (Sanacora et al., 2012).