After I/R injury, the myocardial infarction size was significantly reduced in GSDMD KO mice compared with the WT mice (Figures 1(e) and 1(f)), and the release of serum LDH was also reduced in the GSDMD KO mice (Figure 1(g)), suggesting that GSDMD knockout inhibited the pyroptosis and reduced the myocardial infarction size during the acute phase of myocardial I/R. Here, GSDMD is linked to myocardial infarction.