Although S. epidermidis possesses a smaller number of virulencefactors than Staphylococcus aureus,it maintains a number of cell-wall anchored adhesins that promotebiofilm formation and host infection by binding to extracellular matrixand blood proteins including collagen, fibronectin, and fibrinogen.1,2 These blood and matrix components coat implanted medical devicesas part of the foreign body response and serve as potential reservoirsfor infection. The gene discussed is FN1; the disease is infection.