The levels of TNF-α and TSH and the positive rate of p185 protein in the three groups of patients were compared, the levels of TNF-α and TSH and the positive rate of P185 protein in stage III-IV in the breast cancer group were higher than those in the benign breast group and the healthy group, with statistical significance (P < 0.05), as shown in Table 2. The gene discussed is TNF; the disease is breast cancer.