SOD1 and amyotrophic lateral sclerosis: Many studies have reported the presence of ER stress in ALS and FTD patient’s tissue samples, as well as cellular and animal models of fALS genes like SOD1, VAPB, or FUS (Kikuchi et al., 2006; Gitcho et al., 2009; Chen et al., 2010; Farg et al., 2012).