Aberrant misfolding and aggregation of TDP-43 along with TDP-43 posttranslational modifications play a crucial role in the development of neurodegenerative diseases including ALS and FTD (Arai et al., 2006; Neumann et al., 2006; Igaz et al., 2008; Kumar et al., 2016b; 2019). Here, TARDBP is linked to neurodegenerative disease.