For instance, recent experiments have revealed associations between high serum NfL levels and MRI markers of myelin damage in multiple sclerosis (Yik et al., 2022), pediatric acquired demyelinating syndrome (Simone et al., 2021), and X-linked adrenoleukodystrophy (Weinhofer et al., 2021). Here, NEFL is linked to X-linked adrenoleukodystrophy.