At baseline, it has been positively related to neocortical Aβ and tau in cognitively unimpaired and impaired older adults, respectively (Chatterjee et al., 2018; Benedet et al., 2020) and negatively to hippocampal atrophy in all stages of AD (Mattsson et al., 2017; Hu et al., 2019) and to the mean cortical thickness of the whole-brain and specific brain regions in MCI and cognitively normal older adults (Lee et al., 2022). The gene discussed is MAPT; the disease is hippocampal atrophy.