Moreover, higher plasma concentrations of neurofilament light chain (NfL), the main cytoskeletal structure of myelinated axons, have been associated with increased brain Aβ load in cognitively unimpaired older adults (Chatterjee et al., 2018; Benedet et al., 2020), and have shown to predict cortical thinning and subsequent cognitive impairment in the preclinical stage of both familial and sporadic AD (Preische et al., 2019; Lee et al., 2022). This evidence concerns the gene NEFL and Cognitive impairment.