When with the addition of α-syn to A/T classification framework, PD group and the whole cohort and HC group were divided into eight groups according to CSF Aβ1−42 (A+ or A–) and CSF p-tau (T+ or T–) and α-syn (S+ and S–), and the concentration of CSF sTREM2 was lowest in A+T-S+ group, then higher in A-T-S+ group, and highest in A-T+S- group (Figure 5C and Supplementary Figures S7G,H). Here, MAPT is linked to Parkinson disease.