Because the mutant CAMSAP3 without the CKK domain is incapable of binding to MTs to form proper MT network in the epithelial cells in kidney, Camsap3dc/dc mice developed malfunction of kidneys with cyst at the proximal convoluted tubules starting at E17.5 even though kidney had normal appearance at P21 (Mitsuhata et al., 2021). Here, CAMSAP3 is linked to cyst.