Even the Camsap3-KD mice, which reduce CAMSAP3 expression through RNA processing (Testa et al., 2004; White et al., 2013) without deleting any exons of Camsap3 gene, showed some degree of embryonic lethality, sub-infertility, hydrocephalus, anosmia or hyposmia, sinusitis, respiratory distress, otitis media, and hearing loss (Perez-Garcia et al., 2018; Ingham et al., 2019; Robinson et al., 2020). This evidence concerns the gene CAMSAP3 and Respiratory distress.