MANF represents an emerging regulator of tissue clearance after stroke (Matlik et al., 2018), and at the cellular level, post-stroke MANF delivery supports many endogenous beneficial cellular repair processes that occur after ischemic stroke (Matlik et al., 2018; Tseng et al., 2018; Gao et al., 2020). This evidence concerns the gene MANF and ischemic stroke.