DLG4 and brain ischemia: In cerebral ischemia, the phosphorylation of NR2B can cause neuronal apoptosis by promoting excessive Ca2+ influx, the downregulation of cAMP-response element binding protein (CREB), the activation of JUN, neuronal nitric oxide synthase (nNOS) and post-synaptic density protein 95 (PSD95) (Sun et al., 2015; Dai et al., 2016).