DAPK1 and early-onset autosomal dominant Alzheimer disease: Death-associated protein kinase 1 (DAPK1) is a Ca2+/calmodulin-dependent serine/threonine-protein kinase, which promotes neuronal apoptosis in neurons during various neurological disorders such as ischemic stroke and Alzheimer’s disease (AD) (Shu et al., 2016; Kim et al., 2019; Wang et al., 2020).