NLRP3 and scrapie: However, controversial results in mice have shown that the activity of NLRP3 inflammasome is not necessary for establishing scrapie; thus, the effect of intraventricular injection of PrPsc 106-126 was identical in knockout mice for NLRP3 and pycard (the gene coding for the adapter protein ASC) (Nuvolone et al., 2015).