NLRP3 and Alzheimer disease: Studies on mature ODCs from AD patients and AD transgenic mice demonstrated that NLRP3 inflammasome is active in ODCs and participates in pathologic demyelination through a pathway triggered by hyperactivated Drp1, a mitochondrial GTPase involved in organelle division (Smirnova et al., 2001); this factor inhibits hexokinase 1 (HK1), which in turn activates NLRP3 inflammasome.