GSDMD and nervous system disorder: In a study aimed at investigating if inflammasomes are activated in MS, a neurological disease characterized by loss of neuron-covering myelin, it was observed that in homogenates from postmortem brain samples of MS patients, transcripts from I-1β, IL-18, CASP1, GsdmD, NLRP3, NLRP1 and AIM2 incremented in comparison with control samples; in the same biopsies, it was documented by immunofluorescence that GsdmD co-localized with glutathione S-transferase-π+ (GST-π+), a marker of mature ODCs, indicating specific inflammasome activity in these glial cells (McKenzie et al., 2018).