Thus, in a demyelination model induced by cuprizone feeding in mice, the expression level of Nlrp3 transcript incremented dramatically (> 100 fold); in agreement, in Nlrp3 knockout mice, cuprizone-induced inflammation, demyelination and ODC death were significantly delayed (Jha et al., 2010), suggesting localized activity of Nlrp3 inflammasome in ODCs. This evidence concerns the gene NLRP3 and Peripheral demyelination.