PRKN and Parkinson disease: Additionally, mutations in Parkin, PARK2, PARK6, and PINK1 have been identified in patients with autosomal recessive early-onset PD, and microglia and macrophages from PARK2 and PINK1 knockout mice and patients with PARK2 mutations have been shown to display an exacerbated NLRP3 inflammasome response, possibly due to impaired expression of the anti-inflammatory protein A20 that negatively regulates NLRP3 inflammasome activation (Mouton-Liger et al., 2018).