Cotreatment of Aβ with recombinant TSP1 protein preserved PSD-95 levels and the number of spines, and injection of TSP1 protein in Tg2576 and Tg6799 AD mice increased expression of several synaptic proteins, such as PSD-95 and NR2A (Son et al., 2015). This evidence concerns the gene GRIN2A and Alzheimer disease.