MAPT and neurodegenerative disease: Additionally, these cells are necessary for the elimination of amyloid β (Aβ) peptide and abnormal tau protein, protecting the CNS from the development of neurodegenerative diseases (Bellucci et al., 2004; Hickman et al., 2008; Meyer-Luehmann et al., 2008; Sasaki et al., 2008; Zilka et al., 2009; Nalivaeva et al., 2012; Ries and Sastre, 2016; Perea et al., 2018a, 2020; Španić et al., 2019; Jin et al., 2021; d’Errico et al., 2022).