APP and early-onset autosomal dominant Alzheimer disease: Furthermore, using a transgenic animal model for Alzheimer’s disease (APP/PS1–21 transgenic mouse) that underwent a septic event through cecal ligation and puncture (CLP) surgery, the animals presented increased fibrillar amyloid plaque formation in the hippocampus, in addition to the slight changes found in the microglia (Basak et al., 2021).