IFNG and infectious disease: Considering that infectious diseases lead to the synthesis of several pro-inflammatory cytokines such as IFN-γ, mitochondrial oxidative damage via ROS-induced by pro-inflammatory cytokines could be one of the mechanisms by which infectious diseases lead to neurodegenerative conditions (Brown et al., 1999; Romero et al., 2010; Sturge and Yarovinsky, 2014; Kyuwa and Sugiura, 2020).