Specifically, a stronger association between eGFR and NAFLD was observed in DBP < 90 mmHg (HR = 0.982, 95%CI: 0.980–0.985), FPG ≤ 6.1 mmol/L (HR = 0.982, 95%CI: 0.979-0.985), HDL-c < 1 mmol/L (HR = 0.971, 95%CI: 0.966–0.976), and ALT ≥ 40 U/L (HR = 0.977, 95%CI: 0.971–0.983) participants. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.