A large number of animal experiments showed that long-term exposure to low concentration lead can lead to arterial hypertension, but explain low long-term environmental lead exposure to the influence of high blood pressure, the exact mechanism is unclear, underlying mechanisms including increased oxidative stress, the stimulation of renin-angiotensin system, as well as cut and nitric oxide cyclase guanylic acid (19). The gene discussed is REN; the disease is Hypertension.