The levels of IgG3 in the zinc-deficient group reported sick children with malaria (P = 0.004; 95% CI, 30 to 289%) and those reported sick with malaria and a history of fever in the past 24 h (P = 0.002; 95% CI, 38 to 333%) were significantly and relatively higher than their counterparts in the zinc sufficient group. This evidence concerns the gene IGHG3 and malaria.