The predominantly significant change in IgG3 observed in this study concurs with previous studies for the significant role of IgG3 in conferring protection to malaria (1, 9, 14, 16) and the trend that IgG1 and IgG2 are lower than IgG3 and IgG4, respectively, in asymptomatic children is intriguing (Figure 1). Here, IGHG3 is linked to malaria.