RECQL4 and neoplasm: Studies reported that RECQL4 is not only a metastasis-promoting gene but also a prognostic indicator in breast cancer, as elevated levels of RECQL4 gene amplification, mRNA, and protein demonstrated considerably increased tumor aggressiveness (Thomassen et al., 2009; Santarpia et al., 2013; Arora et al., 2016a; Mo et al., 2018; Zhu et al., 2018).