A polymorphism in RECQL1 A159C had the strongest effect on survival and strongly interacted with other genotypes in RAD54L, XRCC1, and ATM. Although the functional impact of this polymorphism is unknown, it is possible that deficient RECQL1 may lead to an aggressive tumor subtype through increased genomic instability (Li et al., 2006). This evidence concerns the gene RECQL and neoplasm.