In patients with breast cancer, methylation status of WRN was significantly correlated with expression (Li et al., 2016) and an independent study demonstrated that increased expression of WRN mRNA and protein were associated with improved overall survival (OS) and relapse-free survival (RFS) (Shamanna et al., 2016; Zhu et al., 2018). The gene discussed is WRN; the disease is breast carcinoma.