According to previous studies, ALG3 promotes the invasion, migration, and proliferation of oral squamous cell carcinoma (Shao et al., 2021), non-small cell lung cancer (Ke et al., 2020), and breast cancer (Yang et al., 2018; Sun et al., 2021), but the expression of ALG3 and its relation with the prognosis of HCC patients remains unknown. This evidence concerns the gene ALG3 and oral cavity squamous cell carcinoma.