According to previous studies, ALG3 promotes the invasion, migration, and proliferation of oral squamous cell carcinoma (Shao et al., 2021), non-small cell lung cancer (Ke et al., 2020), and breast cancer (Yang et al., 2018; Sun et al., 2021), but the expression of ALG3 and its relation with the prognosis of HCC patients remains unknown. Here, ALG3 is linked to hepatocellular carcinoma.