While, the most significant top four pathways in lower AXL expression group were folate biosynthesis, huntingtons disease, parkinsons disease and oxidative phosphorylation pathways enriched in KEGG terms and fatty acid metabolism, MYC target, reactive oxygen species pathway and oxidative phosphorylation pathway enriched in Hallmark terms (Supplementary Table S1). This evidence concerns the gene AXL and juvenile Huntington disease.