While the economic importance of flavonoids and their related compounds, such as orientin, vitexin, isoorientin, and apigenin, is far-reaching and in fact, speculated to be reaching 1.2 billion US dollars by 2024 [21], the great need for more studies on the effectiveness of these compounds on diabetes-related enzymes especially PTP1B for effective management of T2DM is important. Here, PTPN1 is linked to diabetes mellitus.