GCH1 and major depressive episode: However, as only 2 of the 17 SG members did not use L-Dopa for motor symptoms or antidepressants or were diagnosed with a current, recurrent, or past major depressive episode, it is suggested that autosomal dominant DYT/PARK-GCH1 penetrance can indirectly reach 88.2% in this SG, considering the association of major depressive episode as part of the NMS minimally.