Although CGRP is important in migraine pathophysiology (Goadsby et al., 1990, Ashina et al., 2000, Russo, 2019, Ashina et al., 2019, Edvinsson et al., 2018, Rapoport and McAllister, 2020) and CGRP is expressed in the MN (Warfvinge and Edvinsson, 2019), the role of these MNCGRP neurons in migraine has not previously been explored. Here, CALCA is linked to migraine disorder.