JQ1, a nonselective competitive inhibitor of the BET binding pocket, has previously been shown to attenuate TGFβ-induced Nox4 overexpression, oxidative stress and myofibroblast activity in vitro, as well as bleomycin-induced pulmonary fibrosis in mice (Tang et al., 2013; Stock et al., 2019). Here, NOX4 is linked to pulmonary fibrosis.