BRD4 regulates expression of Nox4, an enzyme required for TGFβ-induced production of reactive oxygen species and fibroblast to myofibroblast transition in pulmonary fibrosis (Hecker et al., 2009; Amara et al., 2010; Hecker et al., 2014). The gene discussed is NOX4; the disease is pulmonary fibrosis.