Altered cell quantification of astrocytes (GFAP) and neurons (NeuN) expression has been described in spina bifida in utero (Reis et al., 2007; Danzer et al., 2011; Oria et al., 2018), but the correlation with the NPC which are the origin of these differentiated cell types it is not understood in spina bifida physiopathology. The gene discussed is RBFOX3; the disease is spina bifida.