Furthermore, studies on relationship between NLRP1 and AD found that the expression of NLRP1 in AD mice was significantly up-regulated, and NLRP1 induced downstream inflammatory cascades through activation of caspase-1, maturation of IL-1β and IL-18 and neuronal death, which further led to the occurrence of AD (Saresella et al., 2016). Here, IL18 is linked to Alzheimer disease.