Research have found that the activation of NLRP3 could induce tau hyperphosphorylation and excessive aggregation, and the activation degree of NLRP3 in the brain of Tau22 mouse model was higher than that in wild-type; interestingly, hippocampus injection with brain homogenate containing Aβ could induce tauopathy in Tau22 mice, however, knocking out of ASC or NLRP3 improved amyloid plaque pathology in APP/PS1 transgenic mice (Ising et al., 2019). This evidence concerns the gene NLRP3 and tauopathy.