SHANK3 and Anxiety: Notably, rodent ASC models utilizing SHANK3 mutations have good face validity, reflecting both repetitive and altered social behavior phenotypes, including reliably increased self-grooming behavior, lower levels of social interaction and ultrasonic vocalization and increased anxiety in a domain-deletion independent manner (Wang et al., 2011; Jaramillo et al., 2016; Mei et al., 2016; Zhou et al., 2016).