NPY and Pruritus: Interestingly, most NPY+ neurons were inactivated following Aβ stimulation in the calcipotriol-treated group (control: 60.0%; calcipotriol-treated: 19.0%, p < 0.0001, chi-squared test, Figure 2A), indicating that NPY+ inhibitory interneurons are silent for gating mechanical itch under chronic itch conditions.