Likewise, in the model of periventricular leukomalacia induced in neonatal rats, treatment with human UC-MSCs preconditioned with IFN-γ increased the preservation of tissue myelin basic protein (MBP) by about 18%, while treatment with control MSCs reached only 2.5% protein preservation, both compared to the untreated group. This evidence concerns the gene MBP and periventricular leukomalacia.