PPP1R15B and metabolic dysfunction-associated steatotic liver disease: Zeng [46] stimulated acupoints, such as “Feng long” (ST40) and “Tai chong” (LR3), in NAFLD rats induced by a high fat diet by blood prick, assessing the expression patterns of FFAs, leptin (LP), adiponectin (ADP), and cAMP response element binding protein (CREP); he found that the level of ADP in the liver of rats increased significantly, while the levels of LP, FFAs, and CREP decreased significantly, thereby proving that acupuncture and purging can promote the body's ability to improve IR, effectively reduce the accumulation of liver lipids, and prevent the progression of NAFLD.