Meanwhile, SENP1 IHC score was higher in the tumor tissue than in the adjacent tissue (n = 157) (p < 0.001) (Figure 1B); SENP1 mRNA expression in the tumor tissue was also elevated than that in the adjacent tissue (n = 102) (p < 0.001) (Figure 1C). The gene discussed is SENP1; the disease is neoplasm.