Moreover, the univariate Cox proportional hazards regression analysis suggested that SENP1 protein (high vs. low) (p = 0.033, HR = 1.816), age (>60 vs. ≤ 60 years) (p = 0.014, HR = 1.887), poor differentiation (p < 0.001, HR = 1.868), tumor size (>5 vs. ≤ 5 cm) (p = 0.002, HR = 2.285), lymph node metastasis (yes vs. no) (p < 0.001, HR = 2.412), TNM stage (III vs. II) (p < 0.001, HR = 2.542), and CA125 (>35 vs. ≤ 35 U/ml) (p = 0.032, HR = 1.671) were correlated with unsatisfying accumulating OS. Here, SENP1 is linked to neoplasm.