The explanation could be that: (1) as mentioned earlier, SENP1 was related to chemotherapy resistance in patients with surgical NSCLC receiving adjuvant chemotherapy (11), further causing unsatisfying DFS and OS and (2) SENP1 expression was correlated with the occurrence of lymph node metastasis and higher TNM stage (as mentioned above), which could indirectly cause poor prognosis. This evidence concerns the gene SENP1 and metastatic malignant neoplasm in the lymph nodes.