Therefore, this study measured the expression of SENP1 by immunohistochemistry (IHC) assay and reverse transcription quantitative PCR (RT-qPCR) detection, with the objective to explore the correlation of SENP1 expression with clinical features, chemotherapy regimen, and prognosis in patients with surgical NSCLC receiving adjuvant chemotherapy. The gene discussed is SENP1; the disease is non-small cell lung carcinoma.