SENP1 and neoplasm: Additionally, according to the univariate Cox proportional hazards regression analysis, SENP1 protein (high vs. low) [p = 0.004, hazard ratio (HR) = 1.889], SENP1 mRNA (high vs. low) (p = 0.032, HR = 1.676), poor differentiation (p = 0.002, HR = 1.524), tumor size (>5 vs. ≤ 5 cm) (p = 0.020, HR = 1.603), lymph node metastasis (yes vs. no) (p = 0.007, HR = 1.679), TNM stage (III vs. II) (p = 0.001, HR = 1.874), and CA125 (>35 vs. ≤ 35 U/ml) (p = 0.034, HR = 1.500) were correlated with shorter accumulating DFS.