PTEN and Familial prostate cancer: For instance, by mediating deSUMOylation of ubiquitin-conjugating enzyme E2T (UBE2T) and the subsequent protein kinase B (Akt) pathway, SENP1 promotes tumor progression in hepatocellular carcinoma (HCC) (12); meanwhile, by modulating epithelial–mesenchymal transition (EMT), SENP1 plays a vital role in invasion and migration of HCC cells (13); by regulating phosphatase and tensin homolog (PTEN) stability, SENP1 facilitates prostate cancer progression (14); SENP1 also involves in irinotecan resistance in colon cancer (15).