Moreover, animal and human studies found that a similar increase in SCFAs protected liver function, reduced intestinal inflammation, and protected against colorectal cancer through regulating CRP level and hepatic lipid metabolism, decreasing proinflammatory Th1 and Th17 cells, and increasing anti-inflammatory immune cells (Alrafas et al., 2020; Ziętek et al., 2021). The gene discussed is CRP; the disease is colorectal cancer.