Another study analyzed the cerebrospinal fluid profiles during the 3–7 days of the course of disease in eight patients with SFTS with suspected acute encephalitis/encephalopathy and found that six patients were positive for SFTSV RNA in cerebrospinal fluid, and MCP-1 and IL-8 levels in cerebrospinal fluid were significantly higher than those in serum (Park et al., 2018) (see the section of “Host immune response–Cytokines–Acute phase–Correlation between cytokines and encephalitis” for details). This evidence concerns the gene CCL2 and Encephalopathy.