Despite the current proposed dengue prognostic parameters, including C-reactive protein polymorphism variants (Mukherjee & Tripathi, 2020), ferritin (Suresh et al., 2020), granulocyte-macrophage colony-stimulating factor (GM-CSF) (Lee et al., 2019), interferon gamma-inducible protein-10 (IP-10) (Chen et al., 2006), and vascular injury biomarkers (Vuong et al., 2021), leaky gut-associated parameters and innate immunity determination are also interesting. This evidence concerns the gene CSF2 and dengue disease.