IL6 and infection: We hypothesize that systemic inflammation (a similar serum IL-6 level in both febrile and critical phases; Table 1) (Leelahavanichkul et al., 2016b), together with the direct DENV infection in enterocytes (Kar et al., 2019) induces gut leakage and gut translocation of several pathogen molecules that facilitates systemic inflammation in both stages of the infection.