For instance, astragalus polysaccharides may inhibit tumorigenesis and lipid metabolism in PCa by mediating the miR-138-5p/SIRT1/SREBP1 pathway (Guo et al., 2020); curcumin blocks the progression of PCa by the suppression of the c-Jun N-terminal kinase (JNK) pathway in a epigenetic regulation-dependent manner (Zhao et al., 2018); and psoralea corylifolia may promote the apoptosis and autophagy of PC-3 cells in prostate cancer (Lin et al., 2018). This evidence concerns the gene SIRT1 and posterior cortical atrophy.