In head and neck squamous cell carcinoma, the expression of cl8-Cer is significantly reduced [59]; in addition, Cer metabolism-related enzymes, such as neutral SM hydrolase 2 (nSMase2 or SMPD3), can increase the level of Cer by hydrolyzing SM to inhibit cell proliferation and prolong cell cycle. Here, CBLN1 is linked to head and neck squamous cell carcinoma.