CBLN1 and esophageal squamous cell carcinoma: At the same time, the results of transcriptome and metabolomic analysis showed that the inhibition of Cer anabolic enzymes and the activation of catabolic enzymes led to the loss of Cer in esophageal cancer tissues, suggesting that the loss of Cer anabolic enzyme expression in esophageal squamous cell carcinoma is passive selection during disease progression.