What is more, we also found that levels of cancer markers CYFRA21-1, CEA, and CA125 were much lower in the observation group than in the control group, implying that the combined regimen of BACE and 125I seed implantation, the direct injection of 125I into the lesions, can significantly improve the drug's ability to kill tumor cells and imped disease progression. This evidence concerns the gene CEACAM5 and neoplasm.