AKT1 and glioblastoma: Dai et al. found that oxymatrine exerts inhibitory effects against GBM cell proliferation and invasion by suppressing the activity of the EGFR/PI3K/AKT/mTOR signaling axis, implying that targeted EGFR inhibitors or PI3K/AKT/mTOR signaling inhibitors may be a reliable therapeutic strategy for GBM [6].