TGFB1, a member of the TGF-β family, plays important roles in cellular growth, tumorigenesis, extracellular matrix accumulation, and tumor metastasis through autocrine and paracrine pathways in various malignant cancers, such as breast cancer, thyroid cancer, pancreatic cancer, gastric cancer, and GBM [21–23]. The gene discussed is TGFB1; the disease is thyroid cancer.