TWIST1 and neoplasm: Studies have shown that epithelial-mesenchymal transformation is vital for the modulation of malignancies, and Twist, Snsnail, N-cadherin, Vimentin, and E-cadherin are pivotal transcriptional factors that regulate the process of epithelial-mesenchymal transformation and are vital for embryo development and tissue genesis [19] Zhang Y, Zhang Y, Zhang Y, et al. Epithelial-mesenchymal transformation is an early marker of tumor invasion and metastases [20].