These ligand‐RAGE interactions are primarily involved in the pathogenesis of various inflammatory diseases such as atherosclerosis, diabetes mellitus, cancer, neurodegenerative disorders (Alzheimer's disease), rheumatoid arthritis, and chronic renal failure (Basta, 2008; Hofmann et al., 2002; Ramasamy et al., 2005; Rong et al., 2005; Schmidt et al., 1999; Schmidt et al., 2001; Taguchi et al., 2000; Tanji et al., 2000). This evidence concerns the gene AGER and early-onset autosomal dominant Alzheimer disease.