A very good example of RAGE inhibitor is FPS‐ZM1 (compound 1), that was found by screening the 5000 compounds that can block the interactions between RAGE V‐domain and Aβ1‐42 to treat Alzheimer's disease (Deane et al., 2012) (Figure 3). The gene discussed is AGER; the disease is early-onset autosomal dominant Alzheimer disease.