Similarly, aminopyrimidine derivatives and phenyl benzoxazoles derivatives discovered a few years back (structures are not provided) were also found to show excellent inhibition in the interactions of RAGE and Aβ1‐42 with the potential to treat AD, however the actual binding mechanism with RAGE was not predicted (Choi et al., 2015; Han et al., 2012). Here, AGER is linked to Alzheimer disease.