TGFBR3 and Stroke: Five single nucleotide polymorphisms (SNPs) tested in children with SCD were significantly associated with stroke risk, namely ANXA2 (rs11853426), TEK (rs489347), and TGFBR3 (rs284875) variants, whereas ADCY9 (rs2238432) and ∝ -thalassemia were linked with decreased stroke risk [8].