As shown, the EMs model mice that received ptgis−/− uterine fragments had dramatically attenuated weights of endometriosis-like lesions in the peritoneal cavity compared to the recipient mice in the WT group (Fig. 3e, f), demonstrating that the activated PTGIS/PGI2 signaling pathway facilitated EMs progression in vivo. This evidence concerns the gene PTGIS and endometriosis.