Strikingly, RNA-binding motif protein 17 (RBM17) was the only splicing factor that was both significantly elevated (P = 0.0086) in the LSC-enriched (LSC + ) vs LSC-devoid (LSC-) subsets from 78 karyotypically normal AML patient samples (GSE76008)8 and strongly linked (P = 0.00568) to poor AML prognosis19 (Fig. 1a–c). This evidence concerns the gene RBM17 and acute myeloid leukemia.