Next, we analyzed the published gene expression profiles of purified LT-HSCs (Lin-CD34+CD38-CD90+) from healthy donors and AML samples with normal karyotype (GSE35008)24, and observed that RBM17 is expressed at significantly higher levels in AML LSCs compared to normal LT-HSCs (Fig. 1d). Here, CD34 is linked to acute myeloid leukemia.