SLU7 and acute myeloid leukemia: To understand the molecular mechanisms that underlie the supporting role of the splicing factor RBM17 in AML, we first performed RBM17 enhanced crosslinking immunoprecipitation (eCLIP)-seq in the K562 myeloid leukemia cell line to identify genome-wide RNA targets bound by RBM17 (Supplementary Fig. 3a).