It is particularly striking that, within these 6 direct splicing targets of RBM17 are EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit)31,32, RBM39 (RNA binding motif protein 39)20,21,33 and HNRNPDL (heterogeneous nuclear ribonucleoprotein D like)34, all factors that have known important roles in cancer stem cell self-renewal and myeloid malignancy. This evidence concerns the gene RBM17 and cancer.