RBM17 and acute myeloid leukemia: Our work clearly demonstrates that EIF4A2 is more highly expressed in LSCs and is required to support the proliferation, survival and undifferentiated state of AML cells, indicating the RBM17/EIF4A2 axis we have uncovered is indeed targetable for AML treatment and that the inhibitory nature of rocaglamide on AML function is likely due largely to its effects on EIF4A2.