TWIST1 and Saethre-Chotzen syndrome: In humans, mutations in TWIST1 cause Saethre-Chotzen syndrome, which is characterized by craniosynostosis and cleft palate, Sweeney-Cox syndrome and Robinow-Sorauf syndrome (Kunz et al., 1999; Takenouchi et al., 2018; Seto et al., 2007).