Farnesoid X receptor (FXR, Nr1h4), a nuclear receptor, is an important receptor for bile acids.[14] Our previous study demonstrated that long‐term systemic FXR activation increases adipose tissue secretion of adiponectin, which circulates in plasma and improves cardiac function after MI.[15] Several bile acids, which are the natural ligands for FXR, have been found to be involved in the process of metabolic and cardiovascular diseases.[16, 17] However, the role of bile acids/FXR in MSC‐based therapy for post‐MI cardiac repair has never been investigated. Here, NR1H4 is linked to cardiovascular disorder.