Based upon the endogenous bile acid pool in the myocardial ischemic microenvironment, the survival of intramyocardially injected ADSC overexpressing FXR was significantly increased, and these cells played a key role in promoting angiogenesis, ameliorating cardiomyocyte apoptosis, and improving post‐MI HF. This evidence concerns the gene NR1H4 and myocardial infarction.