A subset of the COVID‐19 samples were stratified according to their PAI‐1 antigen levels (low <50 ng/ml [13.4–46.4 ng/ml]; medium 50–100 ng/ml [51.5–92.3 ng/ml]; high >100 ng/ml [103.3–260 ng/ml]) and clots lysis studies performed with alteplase and tenecteplase. This evidence concerns the gene SERPINE1 and COVID-19.