In a subset of 4 patients with sufficient paired pre-/post-treatment tissue for IHC analysis, 2 samples from patients with stable disease displayed an increase in CD45 + leukocytes at the tumor–stromal interface, as well as post-treatment decreases in phosphorylated ERK, phosphorylated AKT, and CD31 by Western blot analysis. Here, AKT1 is linked to neoplasm.