Indeed, Jinbo Fu and colleagues demonstrated that aspirin suppressed chemoresistance to 5-FU in 5-FU-resistant CRC cell lines SW620 and SW480 by abrogating 5-FU-induced NF-κB activation, thereby enhancing the antitumor activity of 5-FU [224]. This evidence concerns the gene NFKB1 and colorectal carcinoma.