PTGS2 and cancer: Yet, it is conceivable that activating PIK3CA mutations may lead to (i) increased expression of COX-2 in cancer or cancer-associated endothelial cells, (ii) to increased interaction between polymorphonuclear leukocytes and PIK3CA-mutated colorectal cancer cells, or (iii) to interaction-induced increased expression of 5-lipoxygenase in polymorphonuclear leukocytes, thereby increasing the efficacy of aspirin-triggered local formation of lipid mediators with potential anticancer activity.