Interestingly, Han et al. report in a pre-print that infection of Caco-2 and HT-29 CRC cells lines with F. nucleatum leads to resistance against cetuximab in vitro and in mouse xenografts coinciding with an activation of the PI3K/Akt and JAK/STAT3 pathways in infected cells [327]. Here, PIK3CA is linked to colorectal carcinoma.