PTGS2 and colorectal carcinoma: Although the exact background of the generation of aspirin-triggered lipoxins and resolvins in PIK3CA-mutated and COX-2-overexpressing CRC remains unclear to date, it can, therefore, be postulated that aspirin mediates enhanced generation of these lipid mediators in the presence of increased COX-2 expression and activity, which in turn may contribute to the antitumor effects of the drug.