Phosphorylation of the glycolysis enzyme hexokinase 2 (HK2) by Akt results in increased proliferation, tumorigenesis, and metastasis of colon cancer mediated by NF-κB and hypoxia inducible factor 1α (HIF-1 α) both in vitro and in vivo in mouse xenograft tumors [339]. Here, HK2 is linked to malignant colon neoplasm.