Protection in the upper respiratory tract was less consistent, as AZD7442-TM treatment lowered viral RNA levels in the nasal washes of D614G and BA.1-infected mice but not in BA.1.1 or BA.2-infected mice and failed to reduce D614G, BA.1, BA.1.1, or BA.2 infection in the nasal turbinates (Fig. 2g, h). This evidence concerns the gene CFB and infection.