FOXP3 and chronic obstructive pulmonary disease: Foxp3+GARP+ Tregs in BAL shows a similar pattern of variation in peripheral blood, that is, frequencies of Foxp3+GARP+ Tregs decreased whereas Foxp3+GARP− T cells increased in COPD patients and associated with the severity of multi-organ loss of tissue phonotype (Fig. 7A, B).