NLRP3 and Cognitive impairment: Since multiple inflammasome-associated proteins including NLRP3, IL-18 and IL-1β, have been shown to be upregulated in migraine [33, 34], we hypothesized that P2X7R might participate in the development of cognitive dysfunction in migraine by activating NLRP3 inflammasome signaling pathway, which may induce the gliosis and neuronal loss in the cerebral cortex and hippocampus, and impairment of white matter, ultimately resulting in cognitive impairment.